Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.
Identifieur interne : 001647 ( Main/Exploration ); précédent : 001646; suivant : 001648Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation.
Auteurs : Ji Hye Yoon [Corée du Sud] ; Tae-Gyu Lim ; Kyung Mi Lee ; Ae Ji Jeon ; Su Yeon Kim ; Ki Won LeeSource :
- Journal of agricultural and food chemistry [ 1520-5118 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Cells, Cultured, Citrus sinensis (chemistry), Cyclooxygenase 2 (genetics), Cyclooxygenase 2 (metabolism), Down-Regulation, Enzyme Activation (drug effects), Enzyme Activation (radiation effects), Epidermis (drug effects), Epidermis (enzymology), Epidermis (metabolism), Epidermis (radiation effects), Flavones (pharmacology), Gene Expression Regulation, Enzymologic (drug effects), Gene Expression Regulation, Enzymologic (radiation effects), Mice, Mitogen-Activated Protein Kinases (genetics), Mitogen-Activated Protein Kinases (metabolism), Plant Extracts (pharmacology), Reactive Oxygen Species (metabolism), Signal Transduction (drug effects), Ultraviolet Rays.
- MESH :
- chemical , genetics : Cyclooxygenase 2, Mitogen-Activated Protein Kinases.
- chemistry : Citrus sinensis.
- drug effects : Enzyme Activation, Epidermis, Gene Expression Regulation, Enzymologic, Signal Transduction.
- enzymology : Epidermis.
- chemical , metabolism : Cyclooxygenase 2, Epidermis, Mitogen-Activated Protein Kinases, Reactive Oxygen Species.
- chemical , pharmacology : Flavones, Plant Extracts.
- radiation effects : Enzyme Activation, Epidermis, Gene Expression Regulation, Enzymologic.
- Animals, Cells, Cultured, Down-Regulation, Mice, Ultraviolet Rays.
Abstract
The present study examined the effects of tangeretin, a polymethoxylated flavonone present in citrus fruits, on ultraviolet B (UVB)-induced cyclooxygenase-2 (COX-2) expression in JB6 P+ mouse skin epidermal cells. Tangeretin suppressed UVB-induced COX-2 expression and transactivation of nuclear factor-κB and activator protein-1 in JB6 P+ cells. Moreover, tangeretin blocked UVB-induced phosphorylation of Akt and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated protein kinase, c-Jun N-terminal kinase, and p38, and attenuated the phosphorylation of MAPK kinases 1/2, 3/6, and 4. Tangeretin also limited the endogenous generation of reactive oxygen species (ROS), thereby protecting the cells against oxidative stress. However, tangeretin did not scavenge the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and influence the nicotinamide adenine dinucleotide phosphate oxidase activity. These results suggest that the anti-inflammatory effects of tangeretin stem from its modulation of cell signaling and suppression of intracellular ROS generation. Tangeretin may have a potent chemopreventive effect in skin cancer.
DOI: 10.1021/jf103204x
PubMed: 21126077
Affiliations:
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sortKey="Lee, Kyung Mi" sort="Lee, Kyung Mi" uniqKey="Lee K" first="Kyung Mi" last="Lee">Kyung Mi Lee</name></author><author><name sortKey="Jeon, Ae Ji" sort="Jeon, Ae Ji" uniqKey="Jeon A" first="Ae Ji" last="Jeon">Ae Ji Jeon</name></author><author><name sortKey="Kim, Su Yeon" sort="Kim, Su Yeon" uniqKey="Kim S" first="Su Yeon" last="Kim">Su Yeon Kim</name></author><author><name sortKey="Lee, Ki Won" sort="Lee, Ki Won" uniqKey="Lee K" first="Ki Won" last="Lee">Ki Won Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21126077</idno><idno type="pmid">21126077</idno><idno type="doi">10.1021/jf103204x</idno><idno type="wicri:Area/PubMed/Corpus">000767</idno><idno type="wicri:Area/PubMed/Curation">000767</idno><idno type="wicri:Area/PubMed/Checkpoint">000767</idno><idno type="wicri:Area/Ncbi/Merge">000C72</idno><idno type="wicri:Area/Ncbi/Curation">000C72</idno><idno 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type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lim, Tae Gyu" sort="Lim, Tae Gyu" uniqKey="Lim T" first="Tae-Gyu" last="Lim">Tae-Gyu Lim</name></author><author><name sortKey="Lee, Kyung Mi" sort="Lee, Kyung Mi" uniqKey="Lee K" first="Kyung Mi" last="Lee">Kyung Mi Lee</name></author><author><name sortKey="Jeon, Ae Ji" sort="Jeon, Ae Ji" uniqKey="Jeon A" first="Ae Ji" last="Jeon">Ae Ji Jeon</name></author><author><name sortKey="Kim, Su Yeon" sort="Kim, Su Yeon" uniqKey="Kim S" first="Su Yeon" last="Kim">Su Yeon Kim</name></author><author><name sortKey="Lee, Ki Won" sort="Lee, Ki Won" uniqKey="Lee K" first="Ki Won" last="Lee">Ki Won Lee</name></author></analytic><series><title level="j">Journal of agricultural and food chemistry</title><idno type="eISSN">1520-5118</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Citrus sinensis (chemistry)</term><term>Cyclooxygenase 2 (genetics)</term><term>Cyclooxygenase 2 (metabolism)</term><term>Down-Regulation</term><term>Enzyme Activation (drug effects)</term><term>Enzyme Activation (radiation effects)</term><term>Epidermis (drug effects)</term><term>Epidermis (enzymology)</term><term>Epidermis (metabolism)</term><term>Epidermis (radiation effects)</term><term>Flavones (pharmacology)</term><term>Gene Expression Regulation, Enzymologic (drug effects)</term><term>Gene Expression Regulation, Enzymologic (radiation effects)</term><term>Mice</term><term>Mitogen-Activated Protein Kinases (genetics)</term><term>Mitogen-Activated Protein Kinases (metabolism)</term><term>Plant Extracts (pharmacology)</term><term>Reactive Oxygen Species (metabolism)</term><term>Signal Transduction (drug effects)</term><term>Ultraviolet Rays</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclooxygenase 2</term><term>Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Enzyme Activation</term><term>Epidermis</term><term>Gene Expression Regulation, Enzymologic</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Epidermis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclooxygenase 2</term><term>Epidermis</term><term>Mitogen-Activated Protein Kinases</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Flavones</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Enzyme Activation</term><term>Epidermis</term><term>Gene Expression Regulation, Enzymologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Down-Regulation</term><term>Mice</term><term>Ultraviolet Rays</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present study examined the effects of tangeretin, a polymethoxylated flavonone present in citrus fruits, on ultraviolet B (UVB)-induced cyclooxygenase-2 (COX-2) expression in JB6 P+ mouse skin epidermal cells. Tangeretin suppressed UVB-induced COX-2 expression and transactivation of nuclear factor-κB and activator protein-1 in JB6 P+ cells. Moreover, tangeretin blocked UVB-induced phosphorylation of Akt and mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated protein kinase, c-Jun N-terminal kinase, and p38, and attenuated the phosphorylation of MAPK kinases 1/2, 3/6, and 4. Tangeretin also limited the endogenous generation of reactive oxygen species (ROS), thereby protecting the cells against oxidative stress. However, tangeretin did not scavenge the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and influence the nicotinamide adenine dinucleotide phosphate oxidase activity. These results suggest that the anti-inflammatory effects of tangeretin stem from its modulation of cell signaling and suppression of intracellular ROS generation. Tangeretin may have a potent chemopreventive effect in skin cancer.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Jeon, Ae Ji" sort="Jeon, Ae Ji" uniqKey="Jeon A" first="Ae Ji" last="Jeon">Ae Ji Jeon</name><name sortKey="Kim, Su Yeon" sort="Kim, Su Yeon" uniqKey="Kim S" first="Su Yeon" last="Kim">Su Yeon Kim</name><name sortKey="Lee, Ki Won" sort="Lee, Ki Won" uniqKey="Lee K" first="Ki Won" last="Lee">Ki Won Lee</name><name sortKey="Lee, Kyung Mi" sort="Lee, Kyung Mi" uniqKey="Lee K" first="Kyung Mi" last="Lee">Kyung Mi Lee</name><name sortKey="Lim, Tae Gyu" sort="Lim, Tae Gyu" uniqKey="Lim T" first="Tae-Gyu" last="Lim">Tae-Gyu Lim</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Yoon, Ji Hye" sort="Yoon, Ji Hye" uniqKey="Yoon J" first="Ji Hye" last="Yoon">Ji Hye Yoon</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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